EBM Calculator#

Evidence-Based Medicine diagnostic test calculator.

Features#

• Sensitivity / Specificity calculation
• PPV / NPV with prevalence adjustment
• Likelihood ratios (LR+ / LR-)
• Number Needed to Treat (NNT)
• Pre/post-test probability conversion

Parameters#

ParameterTypeDefaultRequiredDescription--mode, -mstringdiagnosticNoCalculation mode (diagnostic, nnt, probability)--tp, --true-posint-*True positives (diagnostic mode)--fn, --false-negint-*False negatives (diagnostic mode)--tn, --true-negint-*True negatives (diagnostic mode)--fp, --false-posint-*False positives (diagnostic mode)--prevalence, -pfloat-NoDisease prevalence 0-1 (diagnostic mode)--control-ratefloat-**Control event rate 0-1 (nnt mode)--experimental-ratefloat-**Experimental event rate 0-1 (nnt mode)--pretestfloat-\\\Pre-test probability 0-1 (probability mode)--lrfloat-\\*\*Likelihood ratio (probability mode)--output, -ostringstdoutNoOutput file path

\* Required for diagnostic mode

\\ Required for nnt mode

\\\* Required for probability mode

Output Format#

json

{
  "sensitivity": "float",
  "specificity": "float",
  "ppv": "float",
  "npv": "float",
  "lr_positive": "float",
  "lr_negative": "float",
  "interpretation": "string"
}

Risk Assessment#

Risk IndicatorAssessmentLevelCode ExecutionPython/R scripts executed locallyMediumNetwork AccessNo external API callsLowFile System AccessRead input files, write output filesMediumInstruction TamperingStandard prompt guidelinesLowData ExposureOutput files saved to workspaceLow

Security Checklist#

• No hardcoded credentials or API keys
• No unauthorized file system access (../)
• Output does not expose sensitive information
• Prompt injection protections in place
• Input file paths validated (no ../ traversal)
• Output directory restricted to workspace
• Script execution in sandboxed environment
• Error messages sanitized (no stack traces exposed)
• Dependencies audited

Prerequisites#

No additional Python packages required.

Evaluation Criteria#

Success Metrics#

• Successfully executes main functionality
• Output meets quality standards
• Handles edge cases gracefully
• Performance is acceptable

Test Cases#

1. Basic Functionality: Standard input → Expected output
2. Edge Case: Invalid input → Graceful error handling
3. Performance: Large dataset → Acceptable processing time

Lifecycle Status#

• Current Stage: Draft

• Next Review Date: 2026-03-06

• Known Issues: None

• Planned Improvements:

  • Performance optimization
  • Additional feature support